Below is s selected list of our lab’s publications

For a full list of Young-Pearse publications click here

Moving beyond amyloid and tau to capture the biological heterogeneity of Alzheimer’s disease.

Young-Pearse TL, Lee H, Hsieh YC, Chou V, Selkoe DJ. Trends Neurosci. 2023 Apr 3:S0166-2236(23)00067-X. doi: 10.1016/j.tins.2023.03.005. Epub ahead of print. PMID: 37019812.

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity.

Hsieh YC, Negri J, He A, Pearse RV 2nd, Liu L, Duong DM, Chibnik LB, Bennett DA, Seyfried NT, Young-Pearse TL. Mol Neurodegener. 2022 Sep 21;17(1):61. doi: 10.1186/s13024-022-00558-4. PMID: 36131294; PMCID: PMC9494921.

Loss of endosomal exchanger NHE6 leads to pathological changes in tau in human neurons.

Fernandez MA, Bah F, Ma L, Lee Y, Schmidt M, Welch E, Morrow EM, Young-Pearse TL. Stem Cell Reports. 2022 Sep 13;17(9):2111-2126. doi: 10.1016/j.stemcr.2022.08.001. Epub 2022 Sep 1. PMID: 36055242; PMCID: PMC9481919.

APP and DYRK1A regulate axonal and synaptic vesicle protein networks and mediate Alzheimer’s pathology in trisomy 21 neurons

Wu CI, Vinton EA, Pearse RV 2nd, Heo K, Aylward AJ, Hsieh YC, Bi Y, Adeleye S, Fancher S, Duong DM, Seyfried NT, Schwarz TL, Young-Pearse TL.  Mol Psychiatry. 2022 Apr;27(4):1970-1989. doi: 10.1038/s41380-022-01454-5. Epub 2022 Feb 23. PMID: 35194165; PMCID: PMC9133025.

Stem cell-derived neurons reflect features of protein networks, neuropathology, and cognitive outcome of their aged human donors.
Lagomarsino VN, Pearse RV 2nd, Liu L, Hsieh YC, Fernandez MA, Vinton EA, Paull D, Felsky D, Tasaki S, Gaiteri C, Vardarajan B, Lee H, Muratore CR, Benoit CR, Chou V, Fancher SB, He A, Merchant JP, Duong DM, Martinez H, Zhou M, Bah F, Vicent MA, Stricker JMS, Xu J, Dammer EB, Levey AI, Chibnik LB, Menon V, Seyfried NT, De Jager PL, Noggle S, Selkoe DJ, Bennett DA, Young-Pearse TL.
Neuron. 2021 Aug 26:S0896-6273(21)00578-X. doi: 10.1016/j.neuron.2021.08.003. Online

Assessment of Spontaneous Neuronal Activity In Vitro Using Multi-Well Multi-Electrode Arrays: Implications for Assay Development.
Negri J, Menon V, Young-Pearse TL. eNeuro. 2020 Jan 24;7(1):ENEURO.0080-19.2019. doi: 10.1523/ENEURO.0080-19.2019. Print 2020 Jan/Feb.
PMID: 31896559 Free PMC article.

Complex Neurological Phenotype in Female Carriers of NHE6 Mutations.
Pescosolido MF, Kavanaugh BC, Pochet N, Schmidt M, Jerskey BA, Rogg JM, De Jager PL, Young-Pearse TL, Liu JS, Morrow EM.
Mol Neuropsychiatry. 2019 Apr;5(2):98-108. doi: 10.1159/000496341. Epub 2019 Mar 6. PMID: 31192222 Free PMC article.

Lost in translational biology: Understanding sex differences to inform studies of diseases of the nervous system. Pearse RV 2nd, Young-Pearse TL. Brain Res. 2019 Nov 1;1722:146352. doi: 10.1016/j.brainres.2019.146352. Epub 2019 Jul 25. Review. PMID: 31351977

Graham et. al. 2019

Somatic mosaicism of sex chromosomes in the blood and brain. Graham EJ, Vermeulen M, Vardarajan B, Bennett D, De Jager P, Pearse RV 2nd, Young-Pearse TL, Mostafavi S. Brain Res. 2019 Oct 15;1721:146345. doi: 10.1016/j.brainres.2019.146345. Epub 2019 Jul 23. PMID: 31348909

Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression. Srikanth P, Lagomarsino VN, Pearse RV 2nd, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL. Transl Psychiatry. 2018 Nov 8;8(1):245. doi: 10.1038/s41398-018-0281-9. PMID:30410030

Candidate-based screening via gene modulation in human neurons and astrocytes implicates FERMT2 in Aβ and TAU proteostasis. Sullivan SE, Liao M, Smith RV, White C, Lagomarsino VN, Xu J, Taga M, Bennett DA, De Jager PL, Young-Pearse TL. Hum Mol Genet. 2018 Oct 26. doi: 10.1093/hmg/ddy376. PMID: 30371777

Jin et. al.

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease. Jin M, O’Nuallain B, Hong W, Boyd J, Lagomarsino VN, O’Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. Nat Commun. 2018 Jul 11;9(1):2676. doi: 10.1038/s41467-018-05068-w. PMID: 29992960

Mostafavi et. al. Nature Neuroscience

A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer’s disease. Mostafavi S, Gaiteri C, Sullivan SE, White CC, Tasaki S, Xu J, Taga M, Klein HU, Patrick E, Komashko V, McCabe C, Smith R, Bradshaw EM, Root DE, Regev A, Yu L, Chibnik LB, Schneider JA, Young-Pearse TL, Bennett DA, De Jager PL. Nat Neurosci. 2018 Jun;21(6):811-819. doi: 10.1038/s41593-018-0154-9. Epub 2018 May 25. PMID: 29802388

Shared effects of DISC1 disruption and elevated WNT signaling in human cerebral organoids. Srikanth P, Lagomarsino VN, Muratore CR, Ryu SC, He A, Taylor WM, Zhou C, Arellano M, Young-Pearse TL. Transl Psychiatry. 2018 Apr 12;8(1):77. doi: 10.1038/s41398-018-0122-x. PMID: 29643329

Induced pluripotent stem cells as a model system for Alzheimer’s disease. Sullivan, SE, Young-Pearse TL. Brain Res. 2018 Feb 1; 1656: 98-106. doi: 10.1016/j.brainres.2015.10.005. Review. PMID: 26459988

Cell-type Dependent Alzheimer’s Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability. Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL. Stem Cell Reports. 2017 Dec 12;9(6):1868-1884. doi: 10.1016/j.stemcr.2017.10.015. Epub 2017 Nov 16. PMID: 29153990

Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex. Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL. Dev Biol. 2017 Apr 15;424(2):138-146. doi: 10.1016/j.ydbio.2017.03.007. Epub 2017 Mar 8. PMID: 28284905

Single-Cell Detection of Secreted Aβ and sAPPα from Human IPSC-Derived Neurons and Astrocytes. Liao MC, Muratore CR, Gierahn TM, Sullivan SE, Srikanth P, De Jager PL, Love JC, Young-PearseTL. J Neurosci. 2016 Feb 3;36(5):1730-46. doi: 10.1523/JNEUROSCI.2735-15.2016. PMID: 26843653

Induced pluripotent stem cells as a discovery tool for Alzheimer׳s disease. Sullivan SE, Young-Pearse TL. Brain Res. 2017 Feb 1;1656:98-106. doi: 10.1016/j.brainres.2015.10.005. Epub 2015 Oct 13. Review. PMID: 26459988

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate. Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL. Cell Rep. 2015 Sep 1;12(9):1414-29. doi: 10.1016/j.celrep.2015.07.061. Epub 2015 Aug 20. PMID: 26299970

Comparison and optimization of hiPSC forebrain cortical differentiation protocols. Muratore CR, Srikanth P, Callahan DG, Young-Pearse TL. PLoS One. 2014 Aug 28;9(8):e105807. doi: 10.1371/journal.pone.0105807. eCollection 2014. PMID: 25165848

Stem cells on the brain: modeling neurodevelopmental and neurodegenerative diseases using human induced pluripotent stem cells. Srikanth P, Young-Pearse TL. J Neurogenet. 2014 Mar-Jun;28(1-2):5-29. doi: 10.3109/01677063.2014.881358. Epub 2014 Mar 17. Review. PMID: 24628482

The familial Alzheimer’s disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. Hum Mol Genet. 2014 Jul 1;23(13):3523-36. doi: 10.1093/hmg/ddu064. Epub 2014 Feb 12. PMID: 24524897

Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein. Rice HC, Young-Pearse TL, Selkoe DJ. Biochemistry. 2013 May 14;52(19):3264-77. doi: 10.1021/bi400165f. Epub 2013 May 2. PMID: 23597280

Pancortins interact with amyloid precursor protein and modulate cortical cell migration. Rice HC, Townsend M, Bai J, Suth S, Cavanaugh W, Selkoe DJ, Young-Pearse TL. Development. 2012 Nov;139(21):3986-96. doi: 10.1242/dev.082909. Epub 2012 Sep 19. PMID: 22992957

In utero electroporation followed by primary neuronal culture for studying gene function in subset of cortical neurons. Rice H, Suth S, Cavanaugh W, Bai J, Young-Pearse TL. J Vis Exp. 2010 Oct 8;(44). pii: 2103. doi: 10.3791/2103. PMID: 20972409